You can have one unit connected to the Automap server at a time. This means you can control automapped plug-ins on one SL and non Automap Universal sequencer (such as Ableton Live, Logic) with the other SL. Hence you can have 1 ReMOTE ZeRO SL controlling Mixer channels and a ReMOTE 25 SL to play your Automappped plug-ins.

Simply setup your SL according to the User Guide.